Mechanism
Indication(s)
Product Name
Discovery & Development
Preclinical
Phase 1
Phase 2
Phase 3

HemoGenyx utilizes postnatal human hemogenic endothelial cells (Hu-PHEC cells), discovered by HemoGenyx Co-Founder Dr. Vladislav Sandler, to generate cancer-free hematopoietic stem cells (HSC) for use in transplants to treat blood cancers with superior results.

Hu-PHEC-based technology presents a number of important advantages compared to other existing and developing technologies. Most of these advantages are rooted in the fact that Hu-PHEC are a naturally occurring cell type found in adult and postnatal mammalian tissues. They can easily be isolated and do not require "heavy" manipulation before use. Hu-PHEC are “healthy” because they do not accumulate blood cancer-related mutations and/or chromosomal rearrangements, making them a perfect candidate for autologous (patient-specific) BM/HSC transplantations. In addition, Hu-PHEC can be propagated in vitro, allowing the introduction of therapeutic genes and gene modifications and making them a prime candidate for curative gene therapy applications.

HemoGenyx is developing Hu-PHEC technology based on cells isolated from two different sources:

Hu-PHEC isolated from umbilical cord and placenta

Cord blood is extracted from the vessels of the umbilical cord and placenta of a donor using standard methods. To isolate endothelial cells emptied blood vessels of the tissues are treated using a proprietary method developed by HemoGenyx.

To isolate Hu-PHEC, endothelial cells are sorted using fluorescent activated cell sorting (FACS) using proprietary FDA certified reagents developed by HemoGenyx utilizing proprietary methods (patent pending; PCT Patent Application No. PCT/US2014/065469). Isolated Hu-PHEC are stored for further use in conjunction with standard cord blood cells for further use in transplantation. When needed, both Hu-PHEC and cord blood cells obtained from the same donor are used for hematopoietic transplantation per existing and widely practiced transplantation protocols.

Hu-PHEC isolated from the liver biopsy of a patient

A liver biopsy is obtained from a patient per existing and widely practiced protocols. Endothelial cells are isolated from a liver biopsy of a patient using a proprietary method developed by HemoGenyx.

To isolate Hu-PHEC, endothelial cells are sorted using fluorescent activated cell sorting (FACS) using proprietary FDA certified reagents developed by HemoGenyx utilizing proprietary methods (patent pending; PCT Patent Application No. PCT/US2014/065469). Isolated Hu-PHEC are stored for further use in transplantation. When needed, liver Hu-PHEC are activated and intravenously transplanted to the patient they were obtained from.